active

Retinal

Evidence tier

VERY_LOW

Evidence score

HQ studies

Total studies

Goal scores

Acne

2 studies

Anti Aging

2 studies

Sensitivity

2 studies

Barrier

2 studies

Sebum

2 studies

Brightening

2 studies

Hydration

2 studies

Interactions

antagonism · Glycolic Acid

Retinal (retinaldehyde) is more potent than retinol. Combined with strong AHA, irritation risk is significant.

antagonism · Salicylic Acid

Potent retinoid derivative + BHA increases exfoliation and sensitivity. Alternation recommended.

Citations

DOI:10.1111/j.1600-0625.1998.tb00299.x
<i>In vitro</i> metabolism by human skin and fibroblasts of retinol, retinal and retinoic acid
PMID:41735774
A Single-Center, Open-Label Study to Evaluate the Efficacy and Tolerability of Retinal Encapsulated in a Novel Biomimetic Exosome in the Treatment of Mild-To-Moderate Facial Photodamage.

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