active

Palmitoyl Pentapeptide-4

Evidence tier

MODERATE

Evidence score

HQ studies

Total studies

Goal scores

Acne

7 studies

Brightening

7 studies

Barrier

7 studies

Anti Aging

7 studies

Hydration

7 studies

Sebum

7 studies

Sensitivity

7 studies

Interactions

synergy · Retinol

Matrixyl stimulates collagen synthesis through growth factor-like activity, complementing retinol mechanism of action for anti-aging.

antagonism · Glycolic Acid

Strong acids can break peptide bonds, reducing their efficacy. Peptides work best at neutral pH.

Citations

DOI:10.17762/turcomat.v12i5.974
A Clinical Study on Anti-wrinkle Efficacy of a Cosmetics Containing Oligoarginine Conjugation of Palmitoyl-GHK peptide for Skin Penetrating
PMID:36909866
Double-blind, Randomized Trial on the Effectiveness of Acetylhexapeptide-3 Cream and Palmitoyl Pentapeptide-4 Cream for Crow's Feet.
PMID:40367094
Discovery of HY•1: A Novel Multifunctional Skincare Ingredient With Antiaging and Skin Repair Properties.
DOI:10.3390/ijms20246143
Discovery of a Highly Selective MC1R Agonists Pentapeptide to Be Used as a Skin Pigmentation Enhancer and with Potential Anti-Aging Properties
DOI:10.1111/j.1467-2494.2005.00261.x
Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin<sup>1</sup>
PMID:39858482
Peptides: Emerging Candidates for the Prevention and Treatment of Skin Senescence: A Review.
PMID:39694719
Dually functionalized dendrimer for stimuli-responsive release of active ingredients into the skin.

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