functional

Trehalose

Evidence tier

LOW

Evidence score

HQ studies

Total studies

Goal scores

Barrier

5 studies

Anti Aging

5 studies

Sensitivity

5 studies

Acne

5 studies

Hydration

5 studies

Brightening

5 studies

Sebum

5 studies

Interactions

synergy · Hyaluronic Acid

Trehalose protects cell membranes from desiccation stress while HA provides surface hydration. Multi-mechanism moisturization.

Citations

PMID:37252108
Self‐assembled trehalose amphiphiles as molecular gels: A unique formulation to wax‐free cosmetics
PMID:39384017
Trehalose Prevents IL-4/IL-13-Induced Skin Barrier Impairment by Suppressing IL-33 Expression and Increasing NRF2 Activation in Human Keratinocytes In Vitro.
DOI:10.29296/24999490-2025-03-06
Molecular mechanisms of skin biorevitalization: expression of signaling molecules under the action of trehalose-containing gel
DOI:10.1002/app.44755
Trehalose‐based hydrogel potentially useful for the skin burn treatment
PMID:38606717
Functional properties and skin care effects of sodium trehalose sulfate.

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