active

Tranexamic Acid

Evidence tier

HIGH

Evidence score

HQ studies

Total studies

Goal scores

Anti Aging

8 studies

Sensitivity

8 studies

Acne

8 studies

Sebum

8 studies

Brightening

8 studies

Barrier

8 studies

Hydration

8 studies

Interactions

synergy · Niacinamide

Both independently inhibit melanin transfer but through different mechanisms, providing additive brightening effect.

synergy · Alpha Arbutin

Tranexamic acid inhibits plasmin-induced melanogenesis while arbutin directly inhibits tyrosinase. Complementary anti-pigmentation pathways.

synergy · Azelaic Acid

Azelaic acid selectively targets hyperactive melanocytes while tranexamic acid inhibits UV-induced melanogenesis. Combined use for melasma.

synergy · Ascorbic Acid

Tranexamic acid blocks UV-triggered melanogenesis while vitamin C reduces existing melanin. Multi-target brightening approach.

Citations

PMID:37584240
The efficacy and safety of microneedling with topical tranexamic acid for melasma treatment: A systematic review and meta-analysis.
DOI:10.3390/cosmetics9050108
Mechanism of Action of Topical Tranexamic Acid in the Treatment of Melasma and Sun-Induced Skin Hyperpigmentation
DOI:10.18203/issn.2455-4529.intjresdermatol20183159
Comparative study of localised intradermal microinjection of tranexamic acid and oral tranexamic acid for the treatment of melasma
DOI:10.5650/oleoscience.16.337
Novel Bicontinuous Alpha-Gel Formation with Amphiphilic Tranexamic Acid Derivative and Its Application to Cosmetics
DOI:10.1097/dss.0000000000000769
Skin Pretreatment With Conventional Non-Fractional Ablative Lasers Promote the Transdermal Delivery of Tranexamic Acid
DOI:10.18203/issn.2455-4529.intjresdermatol20193226
Comparative study of oral tranexamic acid and triple combination versus tranexamic acid through microneedling in patients of melisma
DOI:10.1159/000371386
Fractional CO<sub>2</sub> Laser Treatment to Enhance Skin Permeation of Tranexamic Acid with Minimal Skin Disruption